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It will soon be possible to ‘light up’ cancer cells, making them easier to eliminate

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Biochemists from Eastern Piedmont University (UPO) have coordinated an important study that promises to provide new tools. gliomasvery dangerous brain tumors that leave little chance of survival.

In fact, Italian researchers have succeeded in taking an important step in the context of research into new treatments for the treatment of these tumors. they detected a specific fluorescent molecule (referred to as probe 10) selectively binds to the enzyme aldehyde dehydrogenase 1A3 (referred to as ALDH1A3) and “lights up” it. this molecule that can only illuminate tumor cells glioma and not healthy tissue.

Neurosurgeons will be able to use this feature as follows: essential support for total resection of the tumor mass, In the operating room In fact, the main treatment for these tumors is surgical removal in an area that is, to say the least, complex to handle.

Techniques used today to remove these tumors are based on a molecule called fluorescent; But it is not selective as it has no biochemical specificity. The lack of selectivity leads to poor discrimination in illuminating diseased tissue compared to healthy tissue..

Take advantage of specific differences Between ALDH1A3 and other isoenzymes of the same family, it has been possible to develop a highly specific molecule for ALDH1A3, an enzyme common in these tumors. It was possible later actually putting in a device that can only “light up” the tumor cellsis is in a laboratory setting He live.

Coordination of multidisciplinary work, Silvia Garavaglia – Associate Professor of Biochemistry in the UPO Department of Pharmaceutical Sciences – and published in the prestigious journal Communication Biologyof the group nature.

The molecule we isolatedI act like a self-charging glow-in-the-dark tape. light, It is like the walls of children’s rooms that are almost invisible during the day and turn into stars, moon and heart when it gets dark.” Professor Garavaglia explained. “Our probe binds very well to the target enzyme present in large quantities in the tumor and, once illuminated with the right light, reveals its position, allowing the neurosurgeon to work very precisely removing all the cancerous tumor cells.

Professor Silvia Garavaglia and her fellow researchers say they are proud of the work carried out and expect to have a molecule that will be tested at the clinical stage in a few years.
Biochemists’ research is an important starting point for the development of cutting-edge treatments and new technologies to combat these devastating tumors.

Source: Every Eye

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